Influence of a rachitogenic regime on hepatic metabolism in the rat
Stio, M.; Iantomasi, T.; Vincenzini, M.T.; Treves, C.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 183(2): 122-129
1989
ISSN/ISBN: 0037-9026 PMID: 2531020 Document Number: 338876
We have previously reported that rats fed on the Steenbock and Black's rickets-inducing diet (deficient in vitamin D and with an altered Ca/P ratio) show metabolic modifications in kidney and intestinal mucosa. We have therefore decided to investigate if also in liver, seat of vitamin D hydroxylation, changes in the metabolic pattern occur. An increase of mitochondrial NAD+-dependent isocitrate dehydrogenase and a decrease of citrate and ATP content was demonstrated in liver of rachitic rats, together with changes in ATP-citrate lyase and glucose-6-phosphate dehydrogenase activity. The inhibitory effect of ATP on liver mitochondria NAD+-dependent isocitrate dehydrogenase was also studied.