Effects of enflurane and halothane anesthesia on hepatic circulation and hepatic metabolism
Mizukami, S.; Hori, T.; Matsumoto, N.; Miyazaki, T.; Goto, T.; Aikawa, K.; Sato, I.
Masui. Japanese Journal of Anesthesiology 33(11): 1213-1217
1984
ISSN/ISBN: 0021-4892 PMID: 6520920 Document Number: 230797
Effects of enflurane and holothane anesthesia on splanchnic circulation and hepatic metabolism were studied in 36 dogs of 4 groups, namely, hypoxic GO.hivin.E (N2O-O2-enflurane 2.9%, FiO2 0.14), hypoxic GOF (N2O-O2-halothane 1.5%, FiO2 0.14), GO.hivin.E (N2O-O2-Enflurane 2.7%, FiO2 0.5) and GOF (N2O-O2-halothane 1.8%, FiO2 0.5). Hepatic arterial and portal venous blood flows were measured electromagnetically and cardiac output by thermodilution method. Hepatic O2 consumption was calculated from blood flows and O2 contents. Hepatic arterial blood flows decreased significantly in hypoxic GO.hivin.E group, but in other groups decreased moderately. Portal venous blood flows significantly decreased in hypoxic GOF group, but decreased less in hypoxic GO.hivin.E and GO.hivin.E group, but significantly decreased in hypoxic GOF group. GPT was not so elevated in hypoxic GO.hivin.E and GO.hivin.E groups, but significantly elevated in hypoxic GOF and GOF groups. The effects of enflurane anesthesia on hepatic circulation and metabolism were considered to be slighter than that of halothane anesthesia from these results.