Effect of isoflurane, enflurane and halothane on hemodynamics during the induction of anesthesia
Shigematsu, T.; Miyazawa, N.; Hiyama, A.; Yorozu, T.; Kodaka, M.; Doi, J.
Masui. Japanese Journal of Anesthesiology 41(8): 1244-1249
1992
ISSN/ISBN: 0021-4892 PMID: 1433845 Document Number: 396512
The effects of isoflurane(I), halothane(H) and enflurane (E) on hemodynamics of 36 patients (12, 11 and 13, respectively) were studied during the inhalation of 1.5 MAC of each anesthetics before the surgery. Mean arterial pressure (MAP), heart rate (HR), cardiac index(CI), systemic vascular resistance index (SVRI), and stroke volume index (SVI) were measured noninvasively using the automatic blod pressure manometer and the ultrasonic Doppler method (Accucom). MAP decreased with I, E and H, but a larger decrement was observed when E than with H. CI and SVI and H were less than with E. SVRI decreased with I and E but a significant difference was observed between E and H. Each value with I was between those with H and E. These results indicate that isoflurane causes the depression of blood pressure mostly by its effect to decrease afterload during the induction of anesthesia, although its depressing effect is less than that of enflurane.