Could hepatic venous oxygen content be an appropriate index of hepatic oxygen metabolism?
Matsumoto, N.; Miyazaki, T.; Mizukami, S.; Ichiki, A.; Nagasaka, H.; Aikawa, K.; Maruno, Y.; Matsumoto, I.; Hori, T.
Masui. Japanese Journal of Anesthesiology 37(3): 304-310
1988
ISSN/ISBN: 0021-4892 PMID: 3398208 Document Number: 314321
In this study, mutual relationships among hepatic oxygen supply, oxygen consumption, supply/consumption and hepatic venous oxygen content were examined in 37 dogs anesthetized with halothane or isoflurane, for the purpose of inquiring what is the appropriate index of hepatic oxygen metabolism during anesthesia. Hepatic oxygen supply and oxygen consumption were calculated from heptic arterial and portal venous blood flows measured electromagnetically and oxygen content in the artery, the portal vein and the hepatic vein. Hepatic oxygen consumption and hepatic oxygen supply/oxygen consumption correlated positively with hepatic oxygen supply (n=37, r=0.657, P < 0.001 and n=37, r=0.528, P < 0.01). Hepatic venous oxygen content correlated well with hepatic oxygen supply/oxygen consumption on the positive logarithmic curve (n=37, r=0.851, P < 0.001). From these results, the following conclusions could be drawn. 1. The decrease of hepatic oxygen supply usually accompanied the decrease of hepatic oxygen consumption. Nevertheless, if hepatic oxygen supply decreases, heaptic oxygen supply/oxygen consumption will be reduced. 2. Even a small reduction of this ratio accompanies a greater decline of hepatic venous oxygen content. 3. Therefore, hepatic venous oxygen content could be a simple and appropriate index of hepatic oxygen metabolism during anesthesia.