Myocardial metabolism, oxygen demand and oxygen supply during prostaglandin E1 induced hypotension
Suzuki, H.; Asada, M.; Tateyama, T.; Hashimoto, K.; Okazaki, K.; Okutsu, Y.; Okumura, F.
Masui. Japanese Journal of Anesthesiology 43(5): 680-683
1994
ISSN/ISBN: 0021-4892 PMID: 8015154 Document Number: 429286
The effects of hypotensive anesthesia induced by PGE-1 on myocardial metabolism, oxygen demand and oxygen supply were studied. Nine mongrel dogs were anesthetized with pentobarbital and isoflurane. Mean blood pressure (MBP), cardiac output (CO), blood gases (BG), coronary blood flow (CBF), and myocardial tissue oxygen tension (MPO) were measured. Arterial and coronary venous lactate and pyruvate concentrations were also measured. We calculated myocardial oxygen consumption, L/P ratio, excess lactate, oxygen extraction ratio and lactate extraction ratio to estimate the adequacy of myocardial aerobic metabolism. CO and CBF decreased in accordance with MBP depression. Myocardial oxygen consumption decreased significantly with PGE-1 administration. Lactate and pyruvate concentrations, L/P ratio, excess lactate and myocardial tissue oxygen tension were unchanged. These results suggest that PGE-1 exerts no significant effect on myocardial metabolism during hypotensive anesthesia.