Intracellular oxygen activation and molecular mechanisms of oxidative hepatic damage
Loginov, A.S.; Matiushin, B.N.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 5: 3-7
1994
ISSN/ISBN: 0869-6047 PMID: 7519922 Document Number: 429708
The paper deals with the mechanisms responsible for formation of active oxygen forms and with the physiological and toxic aspects of their action on the cell. The active oxygen forms are essential biological energy metabolites, such as mitochondrial respiration and microsomal oxidation. It considers the specific features of the systems of APA by various cells (neutrophils, lymphocytes, fibroblasts, endothelial cells). The results of their authors' own investigations provide evidence for the concept that there is an oxidative damage to hepatocytes in liver damage, which is associated with activation of phagocytes, conversion of xanthine oxidase, inhibition of superoxide dismutase and catalase activity and accumulation of active oxygen forms.