Toxicity of Reldan (Chlorpyrifos-methyl) in Nubian goats
Mohamed, O.S.; el Dirdiri, N.L.; Adam, S.E.
Veterinary and Human Toxicology 31(1): 60-63
1989
ISSN/ISBN: 0145-6296 PMID: 2469246 Document Number: 338750
Eight Nubian goats were given single oral doses of 1200, 600, 300 or 150 mg/kg of Reldan. The 2 goats receiving the highest dose died after 1 and 16 h whereas other animals survived the 7-day observation period. Twelve Nubian goats were given Reldan orally at daily dosages of 600, 300, 150 or 75 mg/kg. The goats died or were killed in extremis between 2 and 25 days. Symptoms of poisoning included restlessness, dyspnoea, tremors, urination and defaecation, grinding of teeth, crying, bloat, convulsions, paresis of the hind limbs, staggering, recumbency and death. PM findings included haemorrhages in lungs, trachea, kidneys, liver, heart, intestines and abomasum, patchy pulmonary congestion, oedema, and emphysema, catarrhal abomasitis and enteritis, necrosis of liver and kidneys, and congestion of the brain. Histological and biochemical changes are also described.