Chronic toxicity of the methyl-polysiloxane "DC antifoam A" in dogs
Child, G.P.; Paquin, H.O.; Deichmann, W.B.
A.M.A. Archives of Industrial Hygiene and Occupational Medicine 3(5): 479-482
1951
ISSN/ISBN: 0096-6703 PMID: 14829079 Document Number: 8476
The methylpolysiloxane "DC antifoam® A" is an effective agent for suppressing the production of foam. For this reason it has found use in the processing of certain foods, in the manufacture of drugs and cosmetics and in the prevention and treatment of bloat. The concentration ratios employed range from 1 part in 100,000 to 1 part in 1,000,000. During the preparation of this silicone and during the processes involving its use in drugs and food manufacture, this substance comes into contact with the industrial worker. The apparent innocuous nature of the material may lead to handling procedures, in particular industrial uses, which require an evaluation of the chronic oral toxicity of the silicone. This study was undertaken to provide such information. "DC antifoam® A," a methylpolysiloxane, ingested in doses of 0.3, 1.0 or 3.0 Gm. per kilogram of dog five days a week for a period of six months did not produce signs or symptoms of toxicity. Mild effects noted were restricted to "chewing" after nearly every "antifoam" meal, and egestion of a moist or loose stool. Specific gross or microscopic pathological changes were not observed with the exception of a deposit of bile in the Kupffer and hepatic cells. The significance of the latter observation is at present not understood. From the results of this investigation it appears reasonable to assume that the traces of "DC antifoam® A" which may be absorbed from time to time by human subjects should prove to be entirely harmless. "DC antifoam® A" is used as an antifoaming agent in the processing of certain foods, drugs and cosmetics.
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