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The effect of ethanol on the antiarrhythmic action of atenolol

Filipek, B.; Krupińska, J.; Librowski, T.; Zebala, K.; Piasecka, I.; Piekoszewski, W.

Polish Journal of Pharmacology and Pharmacy 41(3): 207-211

1989

ISSN/ISBN: 0301-0244
PMID: 2616376
Document Number: 337683
The effect of ethyl alcohol on the antiarrhythmic action of atenolol in the adrenaline-induced arrhythmia model was studied in rats non-dependent and dependent on ethanol. Atenolol administered jointly with ethanol, in a single dose or repeatedly produced a weaker antiarrhythmic effect than when it was given alone. Moreover, a rise in animal mortality was observed, in particular after atenolol administration in the period of intoxication. No significant effect of atenolol on ethanol blood concentration was found.

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