Human leukocyte antigen (HLA) complex and anti-thyroidal antibodies in Graves' disease
Lacka, K.; Kordel, M.; Gembicki, M.
Polski Tygodnik Lekarski 44(7-8): 179-181
1989
ISSN/ISBN: 0032-3756 PMID: 2682567 Document Number: 335142
The study aimed at 1) assessing occurrence of HLA-A, HLA-B and HLA-C antigens in patients with Graves disease in comparison with control group of healthy individuals; 2) determining relationship between circulating serum antimicrosomal and antithyreoglobulin antibodies and selected HLA complex antigens. Human leukocyte antigens A,B and C were detected with serological technique using cytotoxicity test. Thyroidal antimicrosomal and antithyreglobulin antibodies were titrated with radioimmunological solid phase technique while antimembrane antibodies with enzymeimmunological technique. The study involved 50 patients with Graves' disease and 50 healthy individuals. HLA-B8, HLA-B15, HLA-B35, and HLA-Cw3 antibodies were detected more frequently in patients with Grave's disease than in the healthy individuals. Antimicrosomal and antithyreoglobulin antibodies were detected in the same group in 76% and 58% of patients, respectively whereas antimembrane antibodies in 92% of patients. Comparison of the occurrence of thyroidal antimicrosomal and antithyreoglobulin antibodies with the presence of HLA-B8, HLA-B35, HLA-B15 and HLA-Cw3 antigens did not show statistically significant correlation between these two parameters.