Effect of quinpirole on the retrieval of a memory trace in amnesia
Il'iuchenok, R.I.; Dubrovina, N.I.; Parkhomenko, R.I.
Farmakologiia i Toksikologiia 52(2): 24-27
1989
ISSN/ISBN: 0014-8318 PMID: 2568271 Document Number: 335083
In experimental studies on mice it was shown that quinpirole, a selective agonist of dopaminergic postsynaptic D-2 receptors, possessed a pronounced antiamnestic activity. Administration of quinpirole before testing on 2nd and 22nd days reactivated the retrieval of passive avoidance impaired by an amnestic agent. The drug effect depended on the duration of "psychogenic" amnesia. It is suggested that the postsynaptic dopaminergic D-2 receptors are actively involved in the neurochemical mechanisms of memory trace retrieval.