Serial position effect and selective amnesia induced by scopolamine in mice
Watanabe, S.; Yanagisawa, N.
Nihon Shinkei Seishin Yakurigaku Zasshi 20(1): 17-20
2000
ISSN/ISBN: 1340-2544 PMID: 10890019 Document Number: 524407
Mice were trained to run through a maze with six gates, each consisting of three doors - two locked and one unlocked. They learned to choose a correct (unlocked) door at the gates close to the beginning and end better than in the middle, showing the primacy and recency effects of serial learning. A low dose of scopolamine unexpectedly enhanced the primacy effect, while a high dose impaired learning in general. The enhancement of the primacy effect can be explained in terms of reduction of retroactive interference.