Altered electrical responses of B-cells after goldthioglucose-induced lesions in the ventromedial hypothalamus
Pace, C.; Delmo, C.; Lee, R.
Research Communications in Chemical Pathology and Pharmacology 65(3): 401-404
1989
ISSN/ISBN: 0034-5164 PMID: 2510225 Document Number: 334015
Goldthioglucose was used to induce necrosis of the ventromedial hypothalamus in mice. This produced an obese mouse that exhibited syndromes associated with non-insulin dependent diabetes mellitus (NIDDM). We found enhanced glucose-induced electrical activity from B-cells with impaired neurotransmitter input. This information indicates that the electrical events of the B-cell plasma membrane are influenced by altered neurotransmitter input and may play a causal role in the enhanced secretory response.