Effects of central administration of insulin in normal and VMH (ventromedial hypothalamus) lesioned rats on food intake
Thombre, D.P.; Bharathi, S.; Krishnamurthy, N.
Indian Journal of Physiology and Pharmacology 33(4): 207-210
1989
ISSN/ISBN: 0019-5499 PMID: 2695463 Document Number: 341717
Central effects of insulin on 20 min. food intake were studied in rats. Insulin administration in the lateral ventricular cerebrospinal fluid (CSF) did not alter food intake in the intact or lesioned ventromedial hypothalamus (VMH) rats. Wheras, after insulin injection in VMH there was a decrease in food intake. In VMH rats, subcutaneous injection of insulin increased food intake. The present study suggests that CSF insulin is not implicated in short term regulation of food intake, and secondly, peripheral glucoreceptors may play an important role in influencing hypothalamic feeding mechanisms.