Top Abstract Purchase Related
Home
>
Node
>
Subnode

Purine compounds in mitochondria: a quantitative evaluation

Ziegler, M.; Dubiel, W.; Pimenov, A.M.; Tikhonov YuV; Toguzov, R.T.; Henke, W.; Gerber, G.

Biomedica Biochimica Acta 48(1): 57-61

1989

ISSN/ISBN: 0232-766X
PMID: 2775250
Document Number: 333903
Applying a recently developed reverse-phase ion-pair HPLC technique we determined purine compounds in acid extracts of mitochondria isolated from rat and mouse liver, rat renal cortex, and hepatoma. Intramitochondrial purine nucleosides and bases were evaluated quantitatively for the first time. All mitochondria examined contain significant amounts of adenosine, guanosine, inosine, guanine, and hypoxanthine. Moreover, IMP was identified in all extracts. Adenine was detected in traces only. These results are in accordance with the concept of mitochondrial metabolism of purine compounds.

Document emailed within 1 workday
Secure & encrypted payments

Fügner, A.; Hoefke, W. 1971: A sleep-like state in chicks caused by biogenic amines and other compounds; quantitative evaluation Arzneimittel-Forschung 21(8): 1243-1247
Tikhonov, Y.V.; Pimenov, A.M.; Toguzov, R.T.; Grune, T.; Siems, W.; Schmidt, H.; Gerber, G. 1990: Metabolism of purine and pyrimidine compounds in erythrocytes of tumor-bearing mice Biomedica Biochimica Acta 49(2-3): S125-S128
Scholar, E.M.; Dalske, H.F. 1979: Effect of purine compounds on the vascular responsiveness of bovine coronary and lingual arteries Archives Internationales de Pharmacodynamie et de Therapie 238(2): 257-267
Poriadin, G.V.; Makarkov, A.I.; Salmasi, Z.M. 1997: Regulation of expression of the surface structure of the lymphocyte membrane by purine compounds in health and in disease Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1: 42-45
Smith, C.M.; Fontenelle, L.J.; Lalanne, M.; Henderson, J.F. 1974: Inhibition of purine ribonucleotide and phosphoribosyl pyrophosphate synthesis by 6-cyclopentylthio-9-hydroxymethylpurine and structurally related compounds Cancer Research 34(3): 463-467
Diwan, J.J.; Moore, C. 1990: Effects of some protein-reactive compounds on K+ flux into mitochondria Biochemistry International 22(5): 843-848
Klement'eva, I.V.; Efimov, A.Z. 1971: Change in coupling of oxidation and phosphorylation in liver mitochondria following administration of some compounds related to riboflavin Voprosy Meditsinskoi Khimii 17(3): 239-243
Wolski, T. 1978: The choice of medium suitable for the reaction of thiol groups with halogen derivatives in the synthesis of some purine and pyrimidine compounds. I. Synthesis of azathioprine Polish Journal of Pharmacology and Pharmacy 30(4): 593-599
Stozharov, A.N. 1983: Quantitative distribution and partial identification of actin-like protein in rat liver mitochondria Biokhimiia 48(12): 2016-2022
Teller, M.N.; Giner-Sorolla, A.; Stöhrer, G.; Budinger, J.M.; Brown, G.B. 1978: Oncogenicity of purine 3-oxide and unsubstituted purine in rats Cancer Research 38(8): 2229-2232
Fowler, B.; Robins, A.J. 1972: Methods for the quantitative analysis of sulphur-containing compounds in physiological fluids Journal of Chromatography 72(1): 105-111
Isobe, T.; Matsumura, A.; Anno, I.; Nagatomo, Y.; Yoshizawa, T.; Itai, Y.; Nose, T. 2003: Changes in 1H-MRS in glioma patients before and after irradiation: the significance of quantitative analysis of choline-containing compounds No Shinkei Geka. Neurological Surgery 31(2): 167-172
Potter, J.L.; Sadowski, L.; Neal, D. 1990: Evaluation of improved Ektachem chloride slides with respect to purine interference Clinical Chemistry 36(2): 386
Kurzawa, M.; Dembiński, B.; Szydłowska-Czerniak, A.; Sandra, P. 1999: Quantitative determination of selected tricyclic biological active compounds by using capillary electrophoresis Acta Poloniae Pharmaceutica 56(6): 415-417
Bai, A.P.; Guo, Z.R.; Chu, F.M. 2001: Three dimensional quantitative structure-activity relationship of heterocyclic-compounds with di-tert-bultylphenyl inhibitors Yao Xue Xue Bao 36(5): 347-350
Walle, T.; Ehrsson, H. 1971: Quantitative gas chromatographic determination of picogram quantities of amino and alcoholic compounds by electron capture detection Acta Pharmaceutica Suecica 8(1): 27-38
Hahn, J.U.; Scholer, H.F. 1983: Qualitative und quantitative Röntgenanalyse von Schwermetallen in Sedimenten im REM durch Röntgenfluorescenz-Anregung. II: Anwendung - Analyse aux RX qualitative et quantitative de métaux lourds dans les sédiments par fluorescence RX en microscopie électronique à balayage. II. Application - Determination of heavy metals in sediments by X-ray fluorescence in SEM (qualitative and quantitative evaluation). II. Application Fresenius' Zeitschrift für Analytische Chemie 315(8): 683-686
Khramtsov, V.V.; Elinova, V.I.; Goriunova, T.E.; Vaĭner, L.M. 1991: Quantitative determination and reversible modification of sulfhydryl groups in low and high molecular weight compounds using a biradical spin marker Biokhimiia 56(9): 1567-1577
Howorka, K.; Howorka, B. 1972: Quantitative analysis of drug preparations using simple means. 2. Semiquantitative determination of thiomersal and phenyl mercury compounds in ophthalmic solutions Pharmazeutische Praxis 2(Suppl 2): 41
Radeva-Domuschieva, D.; Balevska, P.; Russanov, E. 1978: Changes in the lipid composition of rat liver mitochondria and microsomes and in heart mitochondria after swimming Acta Physiologica et Pharmacologica Bulgarica 4(1): 55-61