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The class II genes of the rat MHC

Diamond, A.G.; Hood, L.E.; Howard, J.C.; Windle, M.; Winoto, A.

Journal of Immunology 142(9): 3268-3274

1989

ISSN/ISBN: 0022-1767
PMID: 2496165
Document Number: 332847
Genes that encode class II Ag from the MHC of the rat, the RT1 region, have been isolated as a series of cosmid clones. The cosmids define two clusters, each of which contains three identifiable sequences; one homologous to .alpha.-chain and two to .beta.-chain genes. Both the serologically identified rat class II Ag have been expressed in mouse L cell fibroblasts after the introduction of each .alpha.-chain gene along with a .beta.-chain gene from the same cluster. There are substantial homologies to the I region of the mouse H-2 complex in the presence, location, orientation, and expression of the six identified sequences from the rat RT1, supporting the view that the overall organization of the two gene complexes has remained conserved since the species separated.

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