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Structure and polymorphism of the HLA class II SB light chain genes

Kappes, D.J.; Arnot, D.; Okada, K.; Strominger, J.L.

EMBO Journal 3(12): 2985-2993

1984

ISSN/ISBN: 0261-4189
PMID: 6098459
Document Number: 237858
The HLA class II region contains at least 3 groups of loci, DR, DC and SB, which play an important role in the immune response [isolated from human B cells]. the antigens encoded at these loci are heterodimers composed of an .alpha. and .beta. chain. The sequence of a complete class II .beta. cDNA clone whose sequence agrees closely with the limited N-terminal protein sequence available for the SB.beta. chain is reported. In addition the structure and coding sequence of genomic SB.beta. clones of 2 different SB haploytypes has been obtained and allows definition of some polymorphic regions. The SB.beta. gene appears to undergo alternate splicing at its 3' end, resulting in expression of 2 different intracytoplasmic regions. Partial sequencing of a 2nd non-allelic SB.beta.-like gene, SX.beta., indicates that it is a psudogene.

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