Intraventricular administration of neurohypophyseal hormones interferes with the development of tolerance to ethanol
Szabó, G.; Kovács, G.L.; Telegdy, G.
Acta Physiologica Hungarica 73(1): 97-103
1989
ISSN/ISBN: 0231-424X PMID: 2711843 Document Number: 332439
The effects of intracerebroventricularly (icv.) administered oxytocin (OXT) and lysine-8-vasopressin (LVP) on the development of hypothermic tolerance to ethanol were investigated. Mice equipped with an icv cannula were pretreated with graded doses of OXT or LVP (3 ng, 300 pg, 30 pg or 3 pg/animal) before the daily intraperitoneal and ethanol (4 g/kg) injection. Two doses of OXT or LVP (3 ng or 300 pg/animal) blocked the development of hypothermic tolerance to ethanol. Similar doses of the peptides were ineffective in inhibiting the gradual decrease in hypothermia upon repeated ethanol administration, which effect was observed in the control group. The data presented show that the central administration of these neurohypophyseal peptides blocks the development of tolerance to ethanol.