Immunologic tolerance after oral administration of reovirus: requirement for two viral gene products for tolerance induction
Rubin, D.; Weiner, H.L.; Fields, B.N.; Greene, M.I.
Journal of Immunology 127(4): 1697-1701
1981
ISSN/ISBN: 0022-1767 PMID: 6974200 Document Number: 181531
We have demonstrated that reovirus type 1, but not type 3, generates serotype-specific immunologic tolerance for DTH responses following oral administration of UV-inactivated virus. As shown by adoptive transfer experiments, the tolerance is secondary to the generation of viral-specific suppressor T cells that are present in spleen and mesenteric lymph nodes. No tolerance was generated when live virus was administered orally. Using recombinant viral clones, it was found that 2 viral gene products were required for tolerance induction; serotype specificity is a property of the viral hemagglutinin (the product of the S1 dsRNA segment). The inability of type 3 reovirus to induce suppression following oral administration is a property of the mu 1C polypeptide (the product of the M2 dsRNA genome segment).