The nature of the factors in immune lymph nodes that stimulate humoral and cellular immune reactions
Novikov, V.I.; Vlasov, A.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 107(4): 460-462
1989
ISSN/ISBN: 0365-9615 PMID: 2470442 Document Number: 329831
In the early period after antigen action, cells of the lymph node draining area of antigen injection produce a factor, which after its administration to intact mice, promotes intensified migration of myelopeptide producers in the bone marrow and increases bone marrow suppressor activity. Factor administration produced 2-3-fold increase in macrophage, peritoneal and lymph node count as compared with control, and 2-4-fold increase in humoral and cellular immune response. The factor consists of three easily identifiable components: Ig, MHC class II determinants and antigen determinants, that form unique complex similar to, or identical with the complexes detected in vivo within 3-6 hours after immunization in serum by other authors.