Adjuvant polyarthritis I: incorporation of quantitative measurements of humoral and cellular immune response
Chang, Y.H.
Journal of Pharmacology and Experimental Therapeutics 201(1): 1-7
1977
ISSN/ISBN: 0022-3565 PMID: 850133 Document Number: 114090
A modified model of adjuvant arthritis is described that permits simultaneous quantitative measurement of the humoral and the cellular immune response to a secondary immunogen (el4 cells) in the arthritic rat. Application of the new model system to mechanism studies is illustrated with cyclophosphamide. The drug is shown to suppress adjuvant arthritis by a combined anti-inflammatory and immunosuppressive action.
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