Possibilities of the immunodiagnosis of erythroleukemia
Tupitsyn, N.N.; Frenkel', M.A.; Volkova, M.A.; Baryshnikov, A.I.
Terapevticheskii Arkhiv 61(4): 127-129
1989
ISSN/ISBN: 0040-3660 PMID: 2763179 Document Number: 329496
The authors describe 6 cases of acute leukemia in which erythroid antigens identified by monoclonal antibodies HAE-3 and HAE-9 (against glycophorin A and antigen of nuclear erythroid cells) were expressed on blasts. The morphocytochemical methods were employed to establish different varieties of leukemia according to the FAB-classification: 2-L1, 2-L2, 1-M2, and 1-M. In 4 cases, the existence of the markers of the early stages of differentiation was shown immunologically. Two patients demonstrated the mixed, variant of leukemia (erythroid-T-cellular and erythroid-myeloid). In 5 out of the 6 cases, the patients turned out refractory to chemotherapy. The lethal outcomes were recorded in the first acute period or in the stage of a relapse (one patient) after a very short 2-month remission.