Acute erythroleukemia with t (3;5) accompanied by hepatocellular carcinoma
Nakagawa, H.; Tanaka, S.; Takashima, T.; Shizumi, Y.; Nishigaki, H.; Horiike, S.; Taniwaki, M.; Misawa, S.; Kashima, K.; Hironaka, T.
International Journal of Hematology 54(3): 213-217
1991
ISSN/ISBN: 0925-5710 PMID: 1660736 Document Number: 381382
A female patient in whom acute nonlymphocytic leukemia (ANLL, FAB-M6) developed during treatment of hepatocellular carcinoma (HCC) is described. Two years after partial hepatectomy and subsequent chemotherapy, leukemia developed following a 2 month preleukemic stage. Chromosomal analysis revealed an abnormal karyotype, 46,XX,-5, + der(5)t(3;5)(q25;q31). The balanced translocation t(3;5) has been observed in all types of ANLL and MDS except for ANLL M3 subtype. We summarize patients with ANLL M6 and t(3;5).