Hemodialysis and the acute-phase response in chronic uremic patients
Trznadel, K.; Luciak, M.; Paradowski, M.; Kubasiewicz-Ujma, B.
International Journal of Artificial Organs 12(12): 762-765
1989
ISSN/ISBN: 0391-3988 PMID: 2482260 Document Number: 328932
In comparison with healthy persons, chronic uremic patients on regular hemodialysis treatment had significantly higher blood serum concentrations of alpha 1-acid glycoprotein, ceruloplasmin and C4 complement component, while levels of haptoglobin, C3 and transferrin were lower. Serum alpha 2-macroglobulin and alpha 1-antitrypsin levels were similar in both groups. Hemodialysis with cuprophan membrane induced only slight changes in some of these glycoproteins during a 48-hour follow-up period. Seven hours after termination of hemodialysis slight, but significant, decreases in blood serum transferrin and alpha 1-antitrypsin concentrations were observed. Hemodialysis thus does not seem to induce a conspicuous acute-phase reaction.