Impaired vessel wall response to venous occlusion in patients with chronic renal failure on maintenance hemodialysis
Winter, M.; Needham, J.; Mackie, I.; Cameron, J.S.
Clinical Nephrology 22(6): 307-313
1984
ISSN/ISBN: 0301-0430 PMID: 6441660 Document Number: 236277
We have studied vessel wall function in two groups of patients with chronic renal failure - 1) conservative treatment only and 2) maintenance hemodialysis. Three proteins synthesized by vascular endothelium-plasminogen activator (PA), factor VIII related antigen (VIII:RAg) and antithrombin III (ATIII) - were assayed before and after a fifteen minute period of venous occlusion. The release of PA was significantly reduced in patients on maintenance hemodialysis as compared to both undialyzed uremics and controls. Lesser amounts of VIII:RAg were also released by hemodialysis patients than by undialyzed uremics. These defects, which are suggestive of vessel wall dysfunction on maintenance hemodialysis, may contribute to the high incidence of arteriopathy and thrombotic disease observed in this group of patients.