Local microviscosity of platelet membranes from patients with chronic renal failure on hemodialysis
Rud'ko, I.A.; Chebotarev, V.N.; Kubatiev, A.A.
Patologicheskaia Fiziologiia i Eksperimental'naia Terapiia 1: 20-22
1994
ISSN/ISBN: 0031-2991 PMID: 8183585 Document Number: 425914
The authors revealed changes occurred in local platelet membrane microviscosity and lower malonic dialdehyde production in response to thrombin in 10 patients with chronic renal failure on hemodialysis, as compared to healthy controls. There was no progressive normalization in membrane microviscosity during hemodialysis. It is suggested that the revealed disturbances may be due, first, to the blockade of altered platelet membrane receptors, second, to the changes occurring in the structure and function of platelet membrane phospholipids, their increased lipid peroxidation and their inability to respond to the specific inductors by producing additional products of lipid oxidation degradation.