Thrombocytic hemostasis and the prostaglandin system at early stages of arterial hypertension
Kolomiets, V.I.; Babak, O.I.; Starchenko, T.G.; Volos, B.E.
Klinicheskaia Meditsina 67(4): 82-85
1989
ISSN/ISBN: 0023-2149 PMID: 2755063 Document Number: 328808
In young patients with borderline arterial hypertension the system of pressor and depressor prostaglandins (PG) is activated with maintenance of their physiological proportion. In patients with I stage essential hypertension a considerable rise in the level of PGF2 alpha and thromboxane determines the system imbalance in the direction of the predominance of pressor components. The platelet hemostatic link in I stage essential hypertension is characterized by an increase in platelet aggregation activity which is mediated by the imbalance of the prostacyclin-thromboxane system in the direction to thromboxane.