The pathogenetic role of the thrombocytic-vascular hemostasis in the development of electric myocardial instability (clinico- experimental study)
Liusov, V.A.; Savchuk, V.I.; Seregin, E.O.; Borodkin, V.V.; Dudaev, V.A.; Volov, N.A.; Ioshina, V.I.
Kardiologiia 31(1): 32-34
1991
ISSN/ISBN: 0022-9040 PMID: 2046242 Document Number: 376304
An experimental model of myocardial instability was developed and the effect of changes in platelet and vascular hemostasis and in the level and ratio of prostaglandins and cyclic nucleotides on coronary heart disease was studied. In the clinical portion of the study cardiac rhythm disorders and blood indices were studied in 129 coronary heart disease patients. In the experimental part 30 rats were administered substances (aspirin or cyclic GMP) having an adverse effect on hemostasis, after which ventricular fibrillation was induced. Blood indices were studied following the stabilization of cardiac rhythm and hemodynamics. It was concluded that changes in platelet and vascular hemostasis and in the level and ratio of prostaglandins and cyclic nucleotides occur prior to the onset of myocardial electrical instability and the development of arryhythmias in coronary heart disease patients. Changes in blood indices in patients with arrthmias were similar to those in rats following the administration of cyclic GMP and the development of myocardial electrical instability, indicating the probable pathogenetic relationship between blood changes and cardiac rhythm disorders.