Antiulcer activity of dibunol in experimental stomach and duodenal ulcers
Shatalov, V.N.; Korman, D.B.; Krutova, T.V.; Sokolov, L.K.; Andrianova, O.P.
Farmakologiia i Toksikologiia 51(3): 60-64
1988
ISSN/ISBN: 0014-8318 PMID: 3410030 Document Number: 326309
The antiulcer effect of two medicinal forms (oil solution, liniment) of dibunol in rats with different models of the stomach and duodenum ulcers was studied. The therapeutic activity of dibunol was evaluated by determining the index of ulcer formation as well as during the morphological and histochemical studies. The two medicinal forms of dibunol possessed equal antiulcer activity by all studied criteria. One should note a characteristic property of dibunol--its ability to produce pronounced epithelialization of ulceroerosive and ulceronecrotic lesions of the mucosa without rough scarring.