Peripheral nerve biopsy for diagnosis of globoid cell leukodystrophy in a dog
Vicini, D.S.; Wheaton, L.G.; Zachary, J.F.; Parker, A.J.
Journal of the American Veterinary Medical Association 192(8): 1087-1090
1988
ISSN/ISBN: 0003-1488 PMID: 3372337 Document Number: 326147
Saphenous nerve biopsy was performed to diagnose globoid cell leukodystrophy in a 3-month-old West Highland White Terrier. The dog had progressive neurological disease that appeared to involve the cerebellum, spinal cord, and lower motor neurons to the hind lambs. Light and transmission electron microscopic findings of the nerve biopsy specimen established the diagnosis. Peripheral nerve biopsy may provide a reliable antemortem method for diagnosis of globoid cell leukodystrophy.