Immuno-lectin histochemistry and ultrastructure in two cases of globoid cell leukodystrophy (Krabbe's disease)
Figols, J.; Zimmer, C.; Warzok, R.; Cervos-Navarro, J.
Clinical Neuropathology 11(6): 312-317
1992
ISSN/ISBN: 0722-5091 PMID: 1335383 Document Number: 391324
Two cases of globoid cell leukodystrophy (Krabbe's disease) have been studied by means of conventional histological, immunohistochemical and ultrastructural methods. Lectins specific for several different carbohydrates, Ricinus communis (RCA-1), peanut agglutinin (PNA), wheat germ agglutinin (WGA) and Concanavalin A (Con A) have been utilized both at optical and ultrastructural level. In both cases a strong positive labeling of the globoid cells could be observed lightmicroscopically. Ultrastructurally immunogold deposits only of RCA-I and WGA in the typical Krabbe's inclusions has been clearly demonstrated.