Effect of prazosin on human prostatic adenoma tissue
Kaminka, M.E.; Zhirnikova, M.L.; Vinarov, A.Z.; Mashkovskiĭ, M.D.; Pytel', I.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 106(8): 187-188
1988
ISSN/ISBN: 0365-9615 PMID: 2458142 Document Number: 324777
The effect of prazosin on epinephrine-induced contractions of human benign prostatic hyperplasia strips was studied. It was shown that prazosin has a pronounced adrenoblocking activity (EC50 = 5.10(-9) g/ml) but fails to affect strip contractions induced by KCL. It is suggested that prazosin can be used in the treatment of patients suffering from benign prostatic hyperplasia.