Comparison of enoxacin, ofloxacin, and norfloxacin concentration in human benign prostatic tissue
Yasumoto, R.; Asakawa, M.
Hinyokika Kiyo. Acta Urologica Japonica 34(8): 1519-1521
1988
ISSN/ISBN: 0018-1994 PMID: 3195414 Document Number: 308677
The penetration of pyridone-carboxylic acid drugs into benign prostatic tissue was examined. Twenty-nine patients were studied; 11 for ofloxacin (OFLX) 10 for enoxacin (ENX); and 8 for norfloxacin (NFLX). These drugs were administered orally at a dose of 200 mg three times one day before and twice on the day of operation. Blood sample was taken 30 min before operation and prostatic tissue sample was taken during operation. The mean prostatic concentration of ENX, OFLX and NFLX was 5.81 +/- 2.95 micrograms/g (range 2.99-7.92), 5.51 +/- 1.79 (3.62-7.19), and 4.42 +/- 1.94 (2.45-7.76), respectively. The mean serum concentration of ENX, OFLX and NFLX was 4.87 +/- 1.39 micrograms/ml (3.13-7.44), 5.36 +/- 1.28 (3.12-8.24), and 2.89 +/- 2.34 (0.87-8.33), respectively. The mean ratio of prostatic concentration/serum concentration of ENX, OFLX and NFLX was 1.21 +/- 0.63 (0.82-3.00), 1.06 +/- 0.31, (0.55-1.54) and 2.06 +/- 1.36 (0.93-4.26), respectively. Our findings suggested that the drugs ENX, OFLX and NFLX are useful for prostatic diseases, especially prostatitis.