Spectral analysis of clerodendrin, isolated from Clerodendron trichotomum Thunb
Chen, Z.N.; Xu, P.J.; Yao, T.R.
Yao Xue Xue Bao 23(10): 789-791
1988
ISSN/ISBN: 0513-4870 PMID: 3257032 Document Number: 324383
Clerodendrin, a flavone glycoside with the structure of apigenin-7-O-diglucuronide, has been isolated once more from the leaves of Clerodendron trichotomum Thunb. by a method of precipitation which is different from that used in the early research. Its complete structure, apigenin-7-O-.beta.-D-glucuronopyranosyl (1 .fwdarw. 2)-.beta.-D-glucuronopyranoside, is elucidated by the combined application of UV, IR, NMR and MS. The glycosylation shifts of the sugar moiety for clerodendrin in 13C NMR show that two glucuronic acids with the .beta.-anomeric carbon are linked to each other in the form of 1 .fwdarw. 2. Clerodendrin showed a hypotensive activity in the rat by measurement of the tail volume pressure in preliminary pharmacological tests.