Disseminated blastomycosis in a pregnant woman successfully treated with amphotericin-B. A case report
Hager, H.; Welt, S.I.; Cardasis, J.P.; Alvarez, S.
Journal of Reproductive Medicine 33(5): 485-488
1988
ISSN/ISBN: 0024-7758 PMID: 3385706 Document Number: 322453
An 18-year-old woman developed disseminated blastomycosis in the 30th week of pregnancy. She was treated with amphotericin-B. Simultaneous maternal-infant blood levels at birth were 1.9 and 1.3 micrograms/mL, respectively. The amphotericin-B level in the amniotic fluid was 0.3 microgram/mL at delivery. The infant was normal and without ill effects from either the blastomycosis or the amphotericin-B. The skin lesions and pulmonary infiltrates in the mother improved rapidly, without unexpected side effects from the therapy. The limited experience with amphotericin-B indicates that it is both well tolerated and effective in this clinical situation.