Interleukin-2 and increased natural killer activity in mice experimentally infected with Aspergillus niger
Benedetto, N.; Sabatini, P.; Sellitto, C.; Romano Carratelli, C.
Microbiologica 11(4): 339-345
1988
ISSN/ISBN: 0391-5352 PMID: 3265173 Document Number: 322224
The authors studied the production and effect of interleukin 2 obtained from T lymphocytes stimulated with Aspergillus niger on populations of LGL cells from the peripheral blood and spleen of infected and non-infected mice. The results show an increase in IL-2 production by T lymphocytes in the spleen. In addition, the data demonstrate an increase in LGL activity in the blood and spleen of infected mice. This was seen as the percentage of growth inhibition towards Aspergillus niger, around the tenth day of infection, and reached a maximum of activity on the fifteenth day. The NK activity of the LGL studied increases both in infected and non-infected mice when IL-2 from T lymphocytes of infected mouse blood and spleen is present.