Cytotoxic activity and IL-1 production in mice infected with Aspergillus niger
Benedetto, N.; Sabatini, P.; Galdiero, E.; Romano Carratelli, C.
Microbiologica 15(3): 243-248
1992
ISSN/ISBN: 0391-5352 PMID: 1501585 Document Number: 395762
In this report, we demonstrate an interaction between macrophages and T lymphocytes during A. nigr infection. Supernatants obtained after 48 hrs adherence of infected peritoneal macrophages were able to increase the cytotoxicity of T lymphocytes. Our results also indicate that macrophage supernatant (MS) from mice, in the first 5 days after challenge, is more active on T cell than MS produced later. Splenic T cells activated by IL-1 from mice at 5 days of infection show a significantly increased cytotoxicity, at 10 days after challenge, the cytotoxicity of T cells activated by IL-1 did not significantly differ from non-activated T cells.