DFMO: an alternative therapeutic agent for human African trypanosomiasis
Breton, J.C.; Bouteille, B.; Sonan, T.
Bulletin de la Societe de Pathologie Exotique et de Ses Filiales 81(3 Part 2): 571-577
1988
ISSN/ISBN: 0037-9085 PMID: 3143490 Document Number: 321812
alpha-Difluoromethyl ornithine (DFMO) irreversibly inhibits ornithine decarboxylase (ODC), an essential enzyme for the synthesis of polyamines, and results in decreased biosynthesis of putrescine and spermidine, factors necessary for cellular multiplication. Use of this chemical agent in Trypanosoma brucei brucei infected mice eradicated the parasite from circulating blood. This treatment is now being developed for use in human pathology.
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