Protein kinase a and C activity of erythrocytes in patients with essential hypertension
Kravtsov, G.M.; Dulin, N.O.; Postnov, I.V.
Kardiologiia 28(5): 96-98
1988
ISSN/ISBN: 0022-9040 PMID: 3411869 Document Number: 320626
Activities of protein kinases A and C in erythrocyte cytoplasmic fraction purified by CM-Sephadex and DEAE-cellulose have been measured. Protein kinase C activity is shown to be 1.6-1.8-fold higher, as compared to controls, in essential hypertension, but remain unchanged in renal hypertension. Protein kinase A activity is slightly elevated in patients with essential hypertension, but the difference is not significant. It is suggested that the increase of protein kinase C activity, and perhaps some other activities as well, in essential hypertension may be a result of altered expression of protooncogenes with protein kinase activities.