Effect of treatment with enalapril maleate on the levels of circulating catecholamines, beta endorphins, prostaglandins, and concentration of sodium in erythrocytes in patients with essential hypertension
Chodakowska, J.; Wocial, B.; Ignatowska-Switalska, H.; Knypl, K.; Brym, E.; Czerniewska, E.; Wacławek-Maczkowska, J.; Jabłońska-Skwiecińska, E.; Drygieniec, D.; Januszewicz, W.
Polski Tygodnik Lekarski 44(12-13): 297-300
1989
ISSN/ISBN: 0032-3756 PMID: 2554261 Document Number: 341147
An effect of enalapril maleate on the activity of renin-angiotensin-aldosterone system and sympathetic reactivity, erythrocyte prostaglandin and sodium levels as well as blood beta-endorphin was investigated in 28 patients with the essential arterial blood hypertension. It was found that enalapril maleate significantly increased plasma renin activity, decreased plasma norepinephrine and its 24-hour excretion, and decreased erythrocyte beta-endorphin and sodium levels. Blood epinephrine and aldosterone levels and their daily excretion remained unchanged similarly to prostaglandins. The above results suggest that a decrease in sympathetic system activity and intracellular sodium concentration may play a role in the hypotensive action of enalapril maleate related to the inhibition of angiotensin II formation.