Anthropometric measures in middle age after exposure to famine during gestation: evidence from the Dutch famine
Stein, A.D.; Kahn, H.S.; Rundle, A.; Zybert, P.A.; van der Pal-de Bruin, K.; Lumey, L.H.
American Journal of Clinical Nutrition 85(3): 869-876
2007
ISSN/ISBN: 0002-9165 PMID: 17344511 DOI: 10.1093/ajcn/85.3.869Document Number: 319880
Background: Few studies in humans have related maternal undernutrition to the size of the adult offspring.Objective: The objective was to assess whether reductions in food intake by pregnant women during the Dutch famine of 1944-1945 were related to offspring length, weight, and indexes of adiposity in middle age.Design: We recruited 1) exposed persons born in western Netherlands between January 1945 and March 1946 whose mothers experienced famine during or immediately preceding pregnancy, 2) unexposed persons born in the same 3 institutions during 1943 or 1947 whose mothers did not experience famine during this pregnancy, and 3) unexposed same-sex siblings of persons in series 1 or 2. Anthropometric measurements (n = 427 males and 529 females) were obtained between 2003 and 2005. We defined 4 windows of gestational exposure (by ordinal weeks 1-10, 11-20, 21-30, and 31 through delivery) on the basis of exposure to a ration of < 900 kcal/d during the whole 10-wk interval.Results: Exposure to reduced rations was associated with increased weight and greater indexes of fat deposition at several tissue sites in women but not in men (P for interaction < 0.01). Measures of length and linear proportion were not associated with exposure to famine.Conclusion: Reduced food availability may lead to increased adiposity later in life in female offspring.