Toxicological studies with recombinant hirudin
Klöcking, H.P.; Güttner, J.; Fink, E.
Folia Haematologica 115(1-2): 75-82
1988
ISSN/ISBN: 0323-4347 PMID: 2459036 Document Number: 317910
After daily administration of 1 mg/kg over a period of 4 weeks, hirudin did not influence growth and general behaviour of the animals. There was no indication of treatment-related effects on the liver and the kidneys, on number and function of thrombocytes, on number and differentiation of white cells or on the erythrocytic system. Haemorrhagic complications did not occur. Formation of antibodies was not detectable. Histopathological changes due to application of r-hirudin were not found. LD50 is greater than 50 mg/kg body weight for intravenous application.