Studies on the nasal epithelium toxicity of adjuvants and recombination hirudin (rHV2) nasal spary
Zhang, Y-Jie.; Hou, J-Ling.; Ma, C-Hua.; Wang, X-Liang.; Chen, M-Xia.; Zhang, Q.
Zhongguo Zhong Yao Za Zhi 30(11): 821-824
2005
ISSN/ISBN: 1001-5302 PMID: 16110860 Document Number: 2535
Objective: To investigate the nasal epithelium toxicity of adjuvants and rHV2 nasal spary(HVS). Method: Ciliary movement were evaluated with in situ toad palate model; The histology assessment of nasal epithelium were carried out after long-lasting and repeated use of HVS. Result and conclusion: Adjuvants included SDS, Brij 35, azone, lecithin, EDTA, menthol, nipagin and thiomersal were able to significantly inhibited the ciliary movement, while tween80, glycyrrhizic acid monoammonium salt, benzalkonium bromide, sodium benzoate and adhensive materials investigated had less influence on it. INS was able to damaged the nasal epithelium, but this effect recovered soon after stoping administration. It was demonstrated that SDS, Brij 35, azone, lecithin, EDTA, menthol, nipagin and thiomersallt had significant cilitoxity, while tween80, glycyrrhizic acid monoammonium salt, benzalkonium bromide, sodium benzoate and adhensive materials investigated had no significance; Chitosan co-administration with some adjuvants may make the cillitoxity severer; It is available that rHV2 be administered by nasal spary.
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