Looking ahead: algebraic thinking about genetics, cell kinetics and cancer
Thilly, W.G.
Iarc Scientific Publications 89: 486-492
1988
ISSN/ISBN: 0300-5038 PMID: 3198232 Document Number: 317244
The cancer cell phenotype is modelled as a set of necessary genetic changes containing from one to three changes for any particular set of developmentally identical cells (tissue). This analysis suggests that a person in whose tissue an early genetic change occurs during ontogeny will perforce have a markedly higher number of cells in single sectors containing the necessary set of genetic changes. It is hypothesized that this numerical expectation is a dominant factor in determining the probability that a particular person will develop a tumour in a particular tissue.