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Etoposide effect on cell cycle kinetics of a human lung cancer cell line

Miyamoto, H.; Ito, M.; Araya, Y.; Takaoka, K.; Isobe, H.; Dosaka, H.; Inoue, S.; Kawakami, Y.; Mizuno, S.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 11(6): 1237-1243

1984

ISSN/ISBN: 0385-0684
PMID: 6732252
Document Number: 239546
The lethal and kinetic effects of Etoposide on a cell line of human small cell carcinoma of the lung (PC-6) were analyzed in vitro using flow cytometric measurement of DNA content. The drug effect is dependent on concentration and exposure time. When PC-6 cells were exposed to Etoposide for 1 hour then washed, a increase of cells in G2 phase was observed followed by prompt recovery. Continuous treatment with Etoposide for 24 hours caused a retardation of S phase transit, and high concentrations (greater than 10 micrograms/ml) resulted in stoppage of the whole cell cycle. This drug may be useful in combination chemotherapy regimens.

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