Effects of fibronectin on cytodifferentiation and cell cycle in a human hepatoma cell line QGY-7703
He, Y.; Huang, Y.; Yang, F.
Hua Xi Yi Ke da Xue Xue Bao 23(4): 381-385
1992
ISSN/ISBN: 0257-7712 PMID: 1338992 Document Number: 392858
The effects of fibronectin (FN) on cytodifferentiation and cell cycle in a human hepatoma cell line QGY-7703 were studied by flow cytometry, electron microscopy, etc. The results indicated that FN inhibited cell proliferation and mitosis; significant differences were noted between the control group and the experimental group (P < 0.01). FN blocked the cell cycle in phase S; cell spreading improved with less cell overlapping, and the growth of monolayer cell was partially restored. The number of microvilli and marginal ruffles decreased and that of mitochondria, Golgi complex, endoplasmic reticulum increased. The findings suggested that FN could partially restore QGY-7703 cell normal phenotype and probably be useful for the treatment of tumor.