Kinetics of cell replication of the uterine cervix. IV. Proliferative loci in the basal cell layer
Rubio, C.A.; Llatjós, M.
Acta Cytologica 26(3): 367-370
1982
ISSN/ISBN: 0001-5547 PMID: 6954819 Document Number: 183805
The sequence of dividing and nondividing cells along the basal cell layer of the uterine cervix of C57B1 mice was investigated 8 h after vincristine injection. Of the basal cells in mitosis, 42.8% were solitary and 57.2% in groups of 2 or more mitoses. In contrast, 99.2% of the mitoses occurring in untreated animals were solitary, and less than 1% were double. These results suggest the existence in the basal cell layer of loci of cell production composed of multiple mitoses. The multiple mitotic loci are not observed spontaneously, due to asynchrony in cell division.