A new variant of platelet aggregation defect
Shen, D.; Wei, W.N.; Wang, A.L.
Chinese Medical Journal 101(8): 543-546
1988
ISSN/ISBN: 0366-6999 PMID: 3148391 Document Number: 315646
This paper presents a group of 200 patients with repeated occurrence of ecchymosis on the extremities and/or menorrhagia occasionally associated with gum bleeding or epistaxis. 152 were female and 48 male, with age ranging from 16 to 42 years. The results of laboratory examinations such as blood platelet count, bleeding time, platelet morphology, platelet adhesiveness and platelet aggregation induced by ADP, epinephrine and ristocetin were all normal. Using SJAMP as a new platelet aggregating agent, 74 cases failed in platelet aggregation, the abnormality rate being 37%. SJAMP, a new anticoagulant isolation from Chinese sea-cucumbers, can induce a special aggregation tracing on normal platelet-rich plasma. Therefore, we consider that the patients with failure of SJAMP-induced aggregation may suffer from a new variant of platelet aggregation defect.