An apparent phosphate selenium interaction in weaner sheep
Hudman, J.F.; Costa, N.D.; Robinson, W.F.
Journal of Trace Elements and Electrolytes in Health and Disease 2(2): 105-109
1988
ISSN/ISBN: 0931-2838 PMID: 2980797 Document Number: 314839
The severity of selenium dependent nutritional myopathy in weaner sheep was increased by the ruminal infusion of soluble phosphate (6.0 g/day). Liver Se concentration was also significantly lower in sheep infused with sodium phosphate than in sheep fed the same diet and infused with sodium chloride. There were no significant differences in Se concentrations of kidney, heart, skeletal muscle or blood. Blood glutathionine peroxidase activity in sheep affected with nutritional myopathy was considerably higher than values generally accepted to indicate Se deficiency. Results indicated that there was an interaction in the animal between Se and phosphate leading to lower liver Se concentrations. Results obtained from sheep intraruminally dosed with 75[Se]selenate suggested that an interaction between Se and phosphate could also occur in the gastrointestinal tract.