Interaction of sheep haptoglobin with trypsin inhibitors
Beĭsembaeva, R.U.; Bimendina, G.B.; Mosolov, V.V.
Biokhimiia 52(5): 777-781
1987
ISSN/ISBN: 0320-9725 PMID: 3109502 Document Number: 298154
It was found that polymeric sheep haptoglobin C interacts with duck egg ovomucoid and with maize trypsin inhibitor. These inhibitors do not block the region in haptoglobin C molecule which is responsible for the formation of its complex with hemoglobin. The binding of the natural protein inhibitors is suggestive of homology of the haptoglobin site involved in the interaction with the substrate-specific site of trypsin. It is assumed that the regions in these protein molecules adjacent to the active and specific sites also possess a high degree of homology.